Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | THRB | P10828 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735810 | 0.90 | LMNA (0.62) | LMNATHRBCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL22735666 | 0.85 | LMNA (0.59) | LMNATHRBCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL22735796 | 0.84 | LMNA (0.60) | LMNATHRBCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL22735761 | 0.83 | LMNA (0.58) | LMNATHRBCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL22735897 | 0.82 | LMNA (0.62) | LMNATHRBCYP3A4CYP2C9MAPT | |
| SCHEMBL22735814 | 0.81 | TP53 (0.56) | LMNATHRBCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL22735668 | 0.80 | LMNA (0.55) | LMNATHRBCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL22735898 | 0.79 | MAPT (0.78) | LMNATHRBMAPTTP53 | |
| SCHEMBL22735649 | 0.79 | LMNA (0.64) | LMNATHRBCYP3A4CYP2C9MAPT | |
| SCHEMBL22400666 | 0.74 | LMNA (0.60) | LMNATHRBMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180510-B2 | Xanthine derivatives and uses thereof as inhibitors of bromodomains of BET proteins | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2021-11-23 | — | — | US | disclosed |
| US-20200377522-A1 | XANTHINE DERIVATIVES AND USES THEREOF AS INHIBITORS OF BROMODOMAINS OF BET PROTEINS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377522-A1 | XANTHINE DERIVATIVES AND USES THEREOF AS INHIBITORS OF BROMODOMAINS OF BET PROTEINS | BET1, BRD4, BRD3 | LMNA 2598/4885THRB 1626/4885CYP3A4 4097/4885 |
| US-11180510-B2 | Xanthine derivatives and uses thereof as inhibitors of bromodomains of BET proteins | BET1, BRD4, BRD3 | LMNA 2781/4885THRB 1631/4885CYP3A4 3918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.