Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480635 | 1.00 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL22736155 | 0.90 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL22716894 | 0.88 | JAK2 (0.34) | GRM4 | |
| SCHEMBL29567573 | 0.88 | JAK2 (0.34) | GRM4 | |
| SCHEMBL22735743 | 0.86 | JAK2 (0.33) | GRM4 | |
| SCHEMBL29480519 | 0.86 | JAK2 (0.33) | GRM4 | |
| SCHEMBL22736180 | 0.84 | MAPK1 (0.34) | MAPK1MELKGRM4TLR8TLR7 | |
| SCHEMBL29567903 | 0.84 | MAPK1 (0.34) | MAPK1MELKGRM4TLR8TLR7 | |
| SCHEMBL22736083 | 0.82 | GRM4 (0.35) | MAPK1GRM4 | |
| SCHEMBL29480594 | 0.82 | GRM4 (0.35) | MAPK1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |