Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 15/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | GCG | P01275 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29480466 | 1.00 | JAK2 (0.35) | JAK2RIPK2JAK1GCG | |
| SCHEMBL29480497 | 0.86 | RIPK2 (0.34) | JAK2RIPK2GCG | |
| SCHEMBL22736254 | 0.86 | RIPK2 (0.34) | JAK2RIPK2GCG | |
| SCHEMBL22736340 | 0.85 | RIPK2 (0.36) | JAK2RIPK2GCG | |
| SCHEMBL29480728 | 0.85 | RIPK2 (0.36) | JAK2RIPK2GCG | |
| SCHEMBL22735965 | 0.84 | RIPK2 (0.34) | JAK2RIPK2JAK1GCG | |
| SCHEMBL29480767 | 0.84 | RIPK2 (0.34) | JAK2RIPK2JAK1GCG | |
| SCHEMBL29480528 | 0.83 | RIPK2 (0.34) | JAK2RIPK2JAK1GCG | |
| SCHEMBL22716880 | 0.82 | JAK2 (0.40) | JAK2JAK1 | |
| SCHEMBL29480583 | 0.82 | JAK2 (0.40) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |