Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735995 | 0.77 | CCNT1 (0.34) | CCNT1CDK9 | |
| SCHEMBL29480630 | 0.74 | FGFR4 (0.35) | FGFR4JAK2JAK3 | |
| SCHEMBL22736003 | 0.64 | — | — | |
| SCHEMBL22735782 | 0.62 | EPHX2 (0.40) | FGFR4CCR8 | |
| SCHEMBL30008783 | 0.55 | JAK2 (0.64) | JAK2JAK3 | |
| SCHEMBL16078083 | 0.54 | PSEN1 (0.38) | FGFR4JAK2JAK3 | |
| SCHEMBL28969004 | 0.54 | ITGB3 (0.43) | — | |
| SCHEMBL28969007 | 0.54 | ITGB3 (0.43) | — | |
| SCHEMBL30009346 | 0.54 | JAK1 (0.65) | JAK2JAK3CCNT1CDK9 | |
| SCHEMBL16072929 | 0.54 | PSEN1 (0.38) | FGFR4JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240586-A1 | NOVEL COMPOUNDS FOR INHIBITION OF JANUS KINASE 1 | MANKIND PHARMA LTD. (IN) | 2020-12-03 | — | — | WO | disclosed |