Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | BAX | Q07812 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 5/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13189723 | 0.81 | MEN1 (0.42) | TSHRLMNASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL12700566 | 0.77 | LTA4H (0.57) | LTA4HNR1H2BAXTSHRLMNA | |
| SCHEMBL12700488 | 0.75 | LTA4H (0.55) | LTA4HNR1H2BAXTSHRLMNA | |
| SCHEMBL19075446 | 0.74 | LTA4H (0.52) | LTA4HNR1H2BAXTSHRLMNA | |
| SCHEMBL21075778 | 0.73 | LTA4H (0.47) | LTA4HNR1H2BAXTSHRLMNA | |
| SCHEMBL8943822 | 0.72 | LTA4H (0.63) | LTA4HNR1H2BAXTSHRLMNA | |
| SCHEMBL8943609 | 0.72 | LTA4H (0.63) | LTA4HNR1H2BAXTSHRLMNA | |
| SCHEMBL22129853 | 0.71 | LTA4H (0.92) | LTA4HNR1H2BAXTSHRMEN1 | |
| SCHEMBL3893562 | 0.71 | LTA4H (0.92) | LTA4HNR1H2BAXTSHRMEN1 | |
| SCHEMBL122719 | 0.71 | LTA4H (0.92) | LTA4HNR1H2BAXTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3492471-B1 | FUSED BICYCLIC COMPOUND FOR INHIBITING ACTIVITY OF TYROSINE KINASE | SHENZHEN TARGETRX INC (CN) | 2020-12-02 | — | — | EP | disclosed |