SCHEMBL22737352

SCHEMBL22737352

Cc1nc2cccc(I)c2c(=O)n1C1CCC(=O)NC1=O

nearest known ligand 0.78

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 19/20 0.78
DDB1 Q16531 18/20 0.78
IKZF3 Q9UKT9 4/20 0.78
TNF P01375 2/20 0.78
IL1B P01584 2/20 0.78
ALDH1A1 P00352 1/20 0.41
CHRM2 P08172 1/20 0.41
OPRM1 P35372 1/20 0.41
CYP1A2 P05177 1/20 0.41
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
TBXA2R P21731 1/20 0.40
IKZF1 Q13422 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL283314 0.89 CRBN (0.79) CRBNDDB1IKZF3TNFIL1B
SCHEMBL282492 0.89 CRBN (0.79) CRBNDDB1IKZF3TNFIL1B
SCHEMBL30001891 0.89 CRBN (0.79) CRBNDDB1IKZF3TNFIL1B
SCHEMBL283184 0.89 CRBN (0.79) CRBNDDB1IKZF3TNFIL1B
SCHEMBL25347071 0.87 DDB1 (0.76) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL15120730 0.87 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL21996834 0.87 CRBN (0.76) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL634577 0.87 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL282749 0.87 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
SCHEMBL25346884 0.87 DDB1 (0.76) CRBNDDB1IKZF3TNFIL1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4180432-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR Sichuan Haisco Pharmaceutical Co., Ltd. (CN) 2023-05-17 EP disclosed
EP-4180427-A1 COMPOUND CAPABLE OF INHIBITING AND DEGRADING ANDROGEN RECEPTORS, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICAL USES THEREOF Sichuan Haisco Pharmaceutical Co., Ltd. (CN) 2023-05-17 EP disclosed
WO-2022111526-A1 BENZENE RING DERIVATIVE, AND COMPOSITION AND PHARMACEUTICAL USE THEREOF 四川海思科制药有限公司 2022-06-02 WO disclosed
WO-2022007903-A1 COMPOUND CAPABLE OF INHIBITING AND DEGRADING ANDROGEN RECEPTORS, AND PHARMACEUTICAL COMPOSITIONS AND PHARMACEUTICAL USES THEREOF 四川海思科制药有限公司 2022-01-13 WO disclosed
WO-2022007824-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR 四川海思科制药有限公司 2022-01-13 WO disclosed
WO-2020239103-A1 BTK INHIBITOR RING DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF 四川海思科制药有限公司 2020-12-03 WO disclosed