Avadomide

Avadomide

SCHEMBL282749

Cc1nc2cccc(N)c2c(=O)n1C1CCC(=O)NC1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 20/20 1.00
DDB1 Q16531 19/20 1.00
IKZF3 Q9UKT9 6/20 1.00
TNF P01375 3/20 1.00
IL1B P01584 3/20 1.00
IKZF1 Q13422 2/20 0.50
TBXA2R P21731 1/20 0.50
BRD4 O60885 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Avadomide SCHEMBL634577 1.00 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL29442249 1.00 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL29359950 1.00 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL15120730 1.00 CRBN (1.00) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL29520051 0.99 CRBN (0.98) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL29519996 0.99 CRBN (0.98) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL15515920 0.99 CRBN (0.98) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL12099722 0.99 CRBN (0.98) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL20495228 0.95 CRBN (0.90) CRBNDDB1IKZF3TNFIL1B
Avadomide SCHEMBL20495583 0.95 CRBN (0.90) CRBNDDB1IKZF3TNFIL1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 926 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250186503-A1 METHODS AND COMBINATIONS FOR TREATMENT AND T CELL MODULATION JUNO THERAPEUTICS, INC. (US) 2025-06-12 US claimed
EP-4327878-A2 COMBINATION OF A CELL THERAPY AND AN IMMUNOMODULATORY COMPOUND Juno Therapeutics, Inc. (US) 2024-02-28 EP claimed
EP-3618842-B1 COMBINATION OF A CELL THERAPY AND AN IMMUNOMODULATORY COMPOUND JUNO THERAPEUTICS INC (US) 2023-10-18 EP claimed
US-11733233-B2 Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases CELGENE CORPORATION (US) 2023-08-22 US claimed
US-20230255975-A1 METHODS FOR TREATING CANCER WITH COMBINATION THERAPIES CELGENE CORPORATION 2023-08-17 US claimed
EP-3641772-B1 TREATMENT OF HEPATOCELLULAR CARCINOMA CHARACTERIZED BY HEPATITIS B VIRUS INFECTION CELGENE CORP (US) 2023-08-02 EP claimed
EP-4171550-A1 METHODS FOR TREATING CANCER WITH COMBINATION THERAPIES Celgene Corporation (US) 2023-05-03 EP claimed
CN-115916191-A Methods of treating cancer with combination therapy 新基公司 2023-04-04 CN claimed
US-20220008477-A1 METHODS AND COMBINATIONS FOR TREATMENT AND T CELL MODULATION JUNO THERAPEUTICS, INC. (US) 2022-01-13 US claimed
US-20220003749-A1 METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS CELGENE CORPORATION (US) 2022-01-06 US claimed
WO-2014004990-A2 METHODS FOR DETERMINING DRUG EFFICACY USING CEREBLON-ASSOCIATED PROTEINS CELGENE CORPORATION (US) 2014-01-03 WO claimed
US-20130183675-A1 BIOMARKERS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA CELGENE CORPORATION (US) 2013-07-18 US claimed
WO-2013106686-A1 BIOMARKERS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA CELGENE CORPORATION (US) 2013-07-18 WO claimed
US-20120322073-A1 METHODS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES USING CEREBLON AS A PREDICTOR CELGENE CORPORATION 2012-12-20 US claimed
WO-2012149299-A2 METHODS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES USING CEREBLON AS A PREDICTOR CELGENE CORPORAITON (US) 2012-11-01 WO claimed
WO-2012125475-A1 USE OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2-6-DIONE IN TREATMENT OF IMMUNE-RELATED AND INFLAMMATORY DISEASES CELGENE CORPORATION (US) 2012-09-20 WO claimed
WO-2012125459-A1 METHODS OF TREATING CANCER USING 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE CELGENE CORPORATION (US) 2012-09-20 WO claimed
WO-2012125438-A1 SOLID FORMS OF 3-(5-AMINO-2METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES CELGENE CORPORATION (US) 2012-09-20 WO claimed
US-20120232100-A1 SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES CELGENE CORPORATION 2012-09-13 US claimed
US-20120230983-A1 METHODS OF TREATING CANCER USING 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE CELGENE CORPORATION 2012-09-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120322073-A1 METHODS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES USING CEREBLON AS A PREDICTOR CRBN, SERPINA6, TSG101 CRBN 1/4885DDB1 946/4885IKZF3 1416/4885
US-20250186503-A1 METHODS AND COMBINATIONS FOR TREATMENT AND T CELL MODULATION ICOS, MDM2, XIAP CRBN 17/4885DDB1 1046/4885IKZF3 54/4885
US-20220003749-A1 METHODS FOR DETERMINING DRUG EFFICACY FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA, MULTIPLE MYELOMA, AND MYELOID CANCERS BCL9, BCL9L, IKZF1 CRBN 5/4885DDB1 52/4885IKZF3 4/4885
US-20230255975-A1 METHODS FOR TREATING CANCER WITH COMBINATION THERAPIES NEK1, NEK11, CDK9 CRBN 1387/4885DDB1 485/4885IKZF3 266/4885
US-20120232100-A1 SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ALPP, DPYD CRBN 785/4885DDB1 2493/4885IKZF3 3449/4885
US-20220008477-A1 METHODS AND COMBINATIONS FOR TREATMENT AND T CELL MODULATION ICOS, MDM2, XIAP CRBN 17/4885DDB1 1046/4885IKZF3 54/4885
US-11733233-B2 Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases CRBN, UBQLN1, UBQLN2 CRBN 1/4885DDB1 247/4885IKZF3 1204/4885
US-20120230983-A1 METHODS OF TREATING CANCER USING 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE VHL, TP53, MGMT CRBN 1487/4885DDB1 593/4885IKZF3 2351/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.