⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1473894 | 0.83 | — | — | |
| SCHEMBL11311213 | 0.83 | — | — | |
| SCHEMBL377 | 0.61 | — | — | |
| Methane SCHEMBL15811862 | 0.55 | — | — | |
| SCHEMBL9738830 | 0.55 | ALDH1A1 (0.50) | — | |
| SCHEMBL11785362 | 0.55 | — | — | |
| SCHEMBL11404941 | 0.50 | — | — | |
| SCHEMBL22041062 | 0.50 | — | — | |
| SCHEMBL20598654 | 0.50 | — | — | |
| SCHEMBL20598980 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4133831-A | CARBON MONOXIDE, CHLORINE, AND A PHOSPHINE CHLORIDE COMPOUND AS CATALYST | UBE INDUSTRIES, LTD. (JP) | 1979-01-09 | — | — | US | claimed |
| JP-54046739-A | — | — | None | — | — | JP | disclosed |
| JP-54061121-A | — | — | None | — | — | JP | disclosed |
| EP-2681214-B1 | BRIDGED PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-03-22 | — | — | EP | disclosed |
| CN-103403003-B | Bridging piperidine derivative | 霍夫曼-拉罗奇有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2536710-B1 | PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-07-13 | — | — | EP | disclosed |
| CN-103025724-B | Piperidine derivatives | HOFFMANN LA ROCHE | 2015-02-11 | — | — | CN | disclosed |
| US-8703763-B2 | Bridged piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-04-22 | — | — | US | disclosed |
| EP-2681214-A1 | BRIDGED PIPERIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-01-08 | — | — | EP | disclosed |
| CN-103403003-A | Bridged piperidine derivatives | HOFFMANN LA ROCHE | 2013-11-20 | — | — | CN | disclosed |
| EP-2536710-A2 | PIPERIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-12-26 | — | — | EP | disclosed |
| WO-2012116965-A1 | BRIDGED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-07 | — | — | WO | disclosed |
| US-20120225884-A1 | BRIDGED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-06 | — | — | US | disclosed |
| WO-2011101304-A2 | PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |
| US-20110201605-A1 | HETEROARYL SUBSTITUTED PIPERIDINES | HOFFMANN-LA ROCHE, INC. | 2011-08-18 | — | — | US | disclosed |
| US-4374770-A | FROM AROMATIC ALDEHYDES AND SULFURYL CHLORIDE | EASTMAN KODAK COMPANY (US) | 1983-02-22 | — | — | US | disclosed |
| US-4155932-A | REACTING CHLORINE AND CARBON MONOXIDE WITH A TERTIARY PHOSPHINE OXIDE | UBE INDUSTRIES, INC. (JP) | 1979-05-22 | — | — | US | disclosed |
| JP-S5461121-A | PREPARATION OF CHLOROFORMIC ACID ESTER | UBE IND LTD | 1979-05-17 | — | — | JP | disclosed |
| JP-S5446739-A | PREPARATION OF AROMATIC CARBOXYLIC ACID CHLORIDE | UBE IND LTD | 1979-04-12 | — | — | JP | disclosed |
| US-4133831-A | CARBON MONOXIDE, CHLORINE, AND A PHOSPHINE CHLORIDE COMPOUND AS CATALYST | UBE INDUSTRIES, LTD. (JP) | 1979-01-09 | — | — | US | disclosed |