Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18318950 | 0.84 | NAMPT (0.53) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18318951 | 0.84 | NAMPT (0.53) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18321605 | 0.84 | ALDH1A1 (0.45) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18321604 | 0.84 | ALDH1A1 (0.45) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18321430 | 0.83 | FASN (0.43) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL22710687 | 0.83 | FASN (0.43) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18321427 | 0.83 | FASN (0.43) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18321573 | 0.79 | ALDH1A1 (0.44) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL18321574 | 0.79 | ALDH1A1 (0.44) | FASNKDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL31696873 | 0.79 | ALDH1A1 (0.44) | FASNKDM4EHTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310773-B1 | SUBSTITUTED 4-BENZYL AND 4-BENZOYL PIPERIDINE DERIVATIVES | 89BIO LTD (IL) | 2020-12-02 | — | — | EP | disclosed |