Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRN | P28799 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22739361 | 0.83 | TSHR (0.39) | TSHRHPGDSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22739234 | 0.71 | TSHR (0.40) | TSHRHPGDSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22727335 | 0.69 | TSHR (0.44) | TSHRHPGDSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22727569 | 0.67 | TSHR (0.43) | TSHRHPGDSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7964347 | 0.62 | SCN9A (0.43) | TSHRHPGDSCN9AKCNH2GRIN1 | |
| SCHEMBL11783170 | 0.61 | TSHR (0.54) | TSHRHPGDSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11782487 | 0.61 | TSHR (0.50) | TSHRHPGDSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2432947 | 0.60 | SLC6A4 (0.44) | HPGDSCN9ASLC6A4GRIN1GRIN2B | |
| SCHEMBL2432944 | 0.60 | SLC6A4 (0.44) | HPGDSCN9ASLC6A4GRIN1GRIN2B | |
| SCHEMBL6568396 | 0.60 | TSHR (0.53) | TSHRHPGDSCN9ASIGMAR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243142-A1 | FUSED HETEROCYCLIC DERIVATIVES AS ANTIVIRAL AGENTS | Janssen Sciences Ireland Unlimited Company (IE) | 2020-12-03 | — | — | WO | disclosed |