Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 13/20 | 0.71 |
| ▸ | PRMT5 | O14744 | 12/20 | 0.68 |
| ▸ | ADK | P55263 | 1/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29524639 | 1.00 | METTL3 (0.71) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL22717075 | 0.86 | METTL3 (0.52) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL18571854 | 0.86 | METTL3 (0.79) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL18572252 | 0.85 | METTL3 (0.72) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL18571855 | 0.85 | METTL3 (0.86) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL18572258 | 0.85 | METTL3 (0.72) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL22002310 | 0.85 | METTL3 (0.72) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL18571818 | 0.85 | METTL3 (0.72) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL18572213 | 0.84 | METTL3 (0.71) | METTL3PRMT5ADKWDR77 | |
| SCHEMBL18571225 | 0.84 | METTL3 (0.69) | METTL3PRMT5ADKWDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243178-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2020-12-03 | — | — | WO | disclosed |