Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142687 | 0.77 | GAA (0.77) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL7827916 | 0.77 | MEN1 (0.68) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL22743592 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL5183778 | 0.76 | GAA (0.76) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL29351970 | 0.76 | GAA (0.76) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL28712302 | 0.76 | GAA (0.70) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL29388992 | 0.76 | GAA (0.70) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL15145824 | 0.76 | GAA (0.70) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL16010975 | 0.75 | EGFR (0.63) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL22743048 | 0.75 | L3MBTL1 (0.64) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243178-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2020-12-03 | — | — | WO | disclosed |