Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 11/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22744160 | 0.85 | GRM5 (0.35) | MAP4K4MAP3K14GRM5 | |
| SCHEMBL22744231 | 0.82 | MAP3K14 (0.55) | MAP3K14 | |
| SCHEMBL22715280 | 0.82 | MAP3K14 (0.55) | MAP3K14 | |
| SCHEMBL29439411 | 0.82 | MAP3K14 (0.55) | MAP3K14 | |
| SCHEMBL22715283 | 0.82 | MAP3K14 (0.55) | MAP3K14 | |
| SCHEMBL22744244 | 0.79 | MAP4K4 (0.43) | MAP4K4 | |
| SCHEMBL23869894 | 0.79 | GRM5 (0.34) | MAP4K4MAP3K14GRM5 | |
| SCHEMBL22715064 | 0.76 | MAP3K14 (0.56) | MAP3K14 | |
| SCHEMBL22715068 | 0.76 | MAP3K14 (0.56) | MAP3K14 | |
| SCHEMBL22716283 | 0.75 | MAP3K14 (0.58) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239999-A1 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-03 | — | — | WO | disclosed |