Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.42 |
| ▸ | DDX3X | O00571 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.30 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269229 | 0.85 | HDAC6 (0.40) | HDAC6HDAC1HDAC4MAP2K4AOC3 | |
| SCHEMBL2270409 | 0.80 | HDAC6 (0.45) | HDAC6HDAC1HDAC4DDX3XHDAC8 | |
| SCHEMBL2221120 | 0.79 | HDAC6 (0.41) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL2223073 | 0.73 | HDAC6 (0.40) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL2223217 | 0.72 | HDAC1 (0.45) | HDAC6HDAC1HDAC4DDX3XHDAC8 | |
| SCHEMBL2277976 | 0.69 | HDAC6 (0.41) | HDAC6HDAC1HDAC4AOC3 | |
| SCHEMBL2222389 | 0.67 | AOC3 (0.45) | AOC3 | |
| SCHEMBL12517101 | 0.64 | HDAC6 (0.42) | HDAC6HDAC1HDAC4DDX3XHDAC8 | |
| SCHEMBL14297327 | 0.62 | HPGD (0.40) | HDAC6HDAC1HDAC4DDX3XHDAC8 | |
| SCHEMBL3098544 | 0.60 | HDAC6 (1.00) | HDAC6HDAC1HDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |