Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221120 | 0.84 | HDAC6 (0.41) | HDAC6HDAC1HDAC4LMNAHDAC8 | |
| SCHEMBL2269229 | 0.79 | HDAC6 (0.40) | HDAC6HDAC1HDAC4 | |
| SCHEMBL14243906 | 0.73 | HDAC1 (0.41) | HDAC6HDAC1HDAC4LMNAHDAC8 | |
| SCHEMBL2274422 | 0.73 | HDAC6 (0.42) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL2227818 | 0.69 | HDAC1 (0.58) | HDAC6HDAC1HDAC4HDAC8HDAC3 | |
| SCHEMBL2221808 | 0.69 | HDAC8 (0.37) | HDAC6HDAC1HDAC4LMNAHDAC8 | |
| SCHEMBL2224975 | 0.68 | HDAC1 (0.47) | HDAC6HDAC1HDAC4HDAC8HDAC3 | |
| SCHEMBL14297309 | 0.67 | HPGD (0.39) | HDAC6HDAC1HDAC4LMNAHDAC8 | |
| SCHEMBL2223392 | 0.66 | HDAC1 (0.41) | HDAC6HDAC1HDAC4LMNAHDAC8 | |
| SCHEMBL2221964 | 0.66 | HDAC6 (0.41) | HDAC6HDAC1HDAC4HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |