Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22744980 | 0.88 | PIK3CA (0.53) | PIK3CAHDAC1PIK3R1KITPDGFRB | |
| SCHEMBL22745224 | 0.85 | PIK3CA (0.46) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL22732598 | 0.82 | PIK3CA (0.42) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL22745001 | 0.80 | PIK3CA (0.42) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL22745036 | 0.80 | PIK3CA (0.40) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL22732438 | 0.77 | PIK3CA (0.40) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL22744999 | 0.77 | KDR (0.40) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL20813807 | 0.75 | PDE5A (0.42) | PDGFRB | |
| SCHEMBL22732354 | 0.75 | PIK3CA (0.47) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL24392596 | 0.73 | PIK3CA (0.43) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239951-A1 | AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-12-03 | — | — | WO | disclosed |