Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22745039 | 0.85 | PIK3CA (0.48) | PIK3CAHDAC1PIK3R1CLK1PIK3CD | |
| SCHEMBL22745085 | 0.78 | CLK1 (0.38) | PIK3CAHDAC1PIK3R1CLK1ALDH1A1 | |
| SCHEMBL22745036 | 0.77 | PIK3CA (0.40) | PIK3CAHDAC1PIK3R1CLK1ALDH1A1 | |
| SCHEMBL22745223 | 0.75 | PIK3CA (0.51) | PIK3CAHDAC1PIK3R1ALDH1A1MAPT | |
| SCHEMBL22744980 | 0.73 | PIK3CA (0.53) | PIK3CAHDAC1PIK3R1 | |
| SCHEMBL24393211 | 0.71 | ADORA2B (0.57) | ALDH1A1KDM4EMEN1POLBMAPT | |
| SCHEMBL22726042 | 0.70 | CLK1 (0.46) | PIK3CACLK1ALDH1A1KDM4EMAPT | |
| SCHEMBL22744963 | 0.69 | MAP4K4 (0.51) | ALDH1A1MEN1MAPK1KMT2AHSD17B10 | |
| SCHEMBL28445732 | 0.69 | PIK3CA (0.74) | PIK3CAHDAC1PIK3R1PIK3CDPIK3CB | |
| SCHEMBL22732598 | 0.69 | PIK3CA (0.42) | PIK3CAHDAC1GRM5PIK3R1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020239951-A1 | AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-12-03 | — | — | WO | disclosed |