Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29481245 | 1.00 | RPS6KB1 (0.43) | RPS6KB1PDPK1KHKUSP2ALDH1A1 | |
| SCHEMBL30297742 | 0.89 | EGFR (0.44) | KHKUSP2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL22714871 | 0.89 | EGFR (0.44) | KHKUSP2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL22744954 | 0.84 | EGFR (0.41) | KHKUSP2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL28726551 | 0.84 | EGFR (0.41) | KHKUSP2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL22715085 | 0.84 | CSF1R (0.47) | USP2CYP1A2CYP2D6CYP2C19CLK4 | |
| SCHEMBL28726549 | 0.84 | EGFR (0.41) | KHKUSP2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL24478390 | 0.83 | LMNA (0.50) | RPS6KB1ALDH1A1HSD17B10EPHA2EGFR | |
| SCHEMBL29481165 | 0.83 | LMNA (0.50) | RPS6KB1ALDH1A1HSD17B10EPHA2EGFR | |
| SCHEMBL29544029 | 0.83 | EGFR (0.40) | KHKUSP2ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239931-A | As P2X3Aminoquinazoline derivatives of inhibitors | 奇斯药制品公司 | 2024-06-25 | — | — | CN | claimed |
| CN-114269432-B | As P2X3Aminoquinazoline derivatives of inhibitors | 奇斯药制品公司 | 2024-05-07 | — | — | CN | claimed |
| CN-114269432-A | As P2X3Aminoquinazoline derivatives as inhibitors | 奇斯药制品公司 | 2022-04-01 | — | — | CN | claimed |
| WO-2020239951-A1 | AMINO QUINAZOLINE DERIVATIVES AS P2X3 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-12-03 | — | — | WO | disclosed |