Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SDCBP | O00560 | 4/20 | 0.45 |
| ▸ | SDC2 | P34741 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274569 | 1.00 | LMNA (0.51) | LMNATP53SDCBPSDC2GAA | |
| SCHEMBL13572363 | 0.90 | LMNA (0.45) | LMNATP53SDCBPSDC2GAA | |
| SCHEMBL13572364 | 0.90 | LMNA (0.45) | LMNATP53SDCBPSDC2GAA | |
| SCHEMBL2182460 | 0.90 | LMNA (0.52) | LMNATP53MAPK1THRB | |
| SCHEMBL2177289 | 0.87 | LMNA (0.48) | LMNATP53 | |
| SCHEMBL2179239 | 0.87 | LMNA (0.53) | LMNATP53SDCBPSDC2GAA | |
| SCHEMBL2178235 | 0.87 | LMNA (0.53) | LMNATP53SDCBPSDC2GAA | |
| SCHEMBL2181176 | 0.85 | MEN1 (0.48) | LMNATP53SDCBPSDC2GAA | |
| SCHEMBL2179965 | 0.84 | LMNA (0.51) | LMNATP53SDCBPSDC2GHSR | |
| SCHEMBL2179971 | 0.84 | LMNA (0.51) | LMNATP53SDCBPSDC2GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |