Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 6/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2270085 | 0.87 | JAK1 (0.46) | JAK1HPGDHTR6BCHEKMT2A | |
| SCHEMBL2271302 | 0.82 | JAK1 (0.46) | JAK1HTR6BCHEJAK2TYK2 | |
| SCHEMBL2274747 | 0.80 | KMT2A (0.48) | JAK1KMT2AMEN1ALDH1A1JAK2 | |
| SCHEMBL2274681 | 0.80 | JAK1 (0.59) | JAK1HTR6JAK2TYK2JAK3 | |
| SCHEMBL2273246 | 0.79 | JAK1 (0.52) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2223730 | 0.79 | JAK1 (0.53) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2273826 | 0.79 | JAK1 (0.48) | JAK1HTR6BCHEJAK2TYK2 | |
| SCHEMBL2275305 | 0.78 | JAK1 (0.61) | JAK1HTR6BCHEKMT2AJAK2 | |
| SCHEMBL2276041 | 0.78 | JAK1 (0.48) | JAK1HTR6JAK2TYK2JAK3 | |
| SCHEMBL2226057 | 0.77 | JAK1 (0.51) | JAK1HTR6JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |