Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 1/20 | 0.69 |
| ▸ | NAAA | Q02083 | 1/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.58 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.58 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.58 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | PAM | P19021 | 2/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31131446 | 1.00 | DGKA (0.69) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL17411440 | 1.00 | DGKA (0.69) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL31011402 | 1.00 | DGKA (0.69) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL22920293 | 1.00 | DGKA (0.69) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL22746298 | 1.00 | DGKA (0.69) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL10392579 | 1.00 | DGKA (0.69) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL20562179 | 0.96 | DGKA (0.69) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL22515387 | 0.96 | DGKA (0.63) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL14632706 | 0.95 | DGKA (0.71) | DGKANAAAPRSS1PRSS2PRSS3 | |
| SCHEMBL21425737 | 0.94 | DGKA (0.61) | DGKANAAAPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020243002-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF HEMOCHROMATOSIS | ULTRAGENYX PHARMACEUTICAL INC. (US) | 2020-12-03 | — | — | WO | disclosed |