Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28689598 | 1.00 | GAA (0.62) | GAAPOLBUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL8267885 | 0.89 | GAA (0.78) | GAAPOLBUSP2ALDH1A1MEN1 | |
| SCHEMBL19732956 | 0.89 | GAA (0.78) | GAAPOLBUSP2ALDH1A1MEN1 | |
| SCHEMBL22748855 | 0.85 | SMN1; SMN2 (0.48) | GAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL22758025 | 0.84 | POLB (0.67) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL31383368 | 0.84 | POLB (0.67) | GAAPOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2572171 | 0.80 | MAPK1 (0.55) | GAAPOLBUSP2ALDH1A1TSHR | |
| SCHEMBL14413865 | 0.79 | GAA (0.56) | GAAPOLBUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL19732943 | 0.78 | POLB (0.70) | GAAPOLBUSP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL19732925 | 0.78 | MEN1 (0.62) | GAAPOLBUSP2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026095-A | Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl ] methyl ] -3-oxo-5, 6,8,8 a-tetrahydro-1H-imidazo [1,5-a ] pyrazin-2-yl ] -carboxylic acid | 豪夫迈·罗氏有限公司 | 2022-02-08 | — | — | CN | disclosed |
| WO-2020245246-A1 | ALTERNATIVE PROCESS FOR THE PREPARATION OF 4-PHENYL-5-ALKOXYCARBONYL-2-THIAZOL-2-YL-1,4-DIHYDROPYRIMIDIN-6-YL]METHYL]-3-OXO-5,6,8,8A-TETRAHYDRO-1H-IMIDAZO[1,5-A]PYRAZIN-2-YL]-CARBOXYLIC ACID | F. HOFFMANN-LA ROCHE AG (CH) | 2020-12-10 | — | — | WO | disclosed |