Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 4/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.32 |
| ▸ | WNT1 | P04628 | 3/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20614507 | 1.00 | LRRK2 (0.39) | LRRK2CYP19A1KDM4EKDM4AKDM5C | |
| SCHEMBL23381117 | 0.91 | CYP19A1 (0.43) | LRRK2CYP19A1CYP1B1CA2CA9 | |
| SCHEMBL21955600 | 0.84 | KDM4E (0.41) | KDM4EKDM4AKDM5CKDM4CKDM2A | |
| SCHEMBL22434761 | 0.78 | KDM4E (0.38) | LRRK2CYP19A1KDM4EKDM5CKDM4C | |
| SCHEMBL23008407 | 0.77 | LRRK2 (0.37) | LRRK2CYP19A1KDM4EGSK3BDYRK1A | |
| SCHEMBL23008634 | 0.77 | LRRK2 (0.39) | LRRK2CYP19A1IDH1GSK3BDYRK1A | |
| SCHEMBL19700923 | 0.76 | CYP1B1 (0.59) | LRRK2CYP19A1CYP1B1 | |
| SCHEMBL9963176 | 0.74 | CYP19A1 (0.66) | CYP19A1CA2CA9 | |
| SCHEMBL13872400 | 0.73 | HSD17B1 (0.44) | CYP19A1KDM4EKDM4AKDM5CKDM4C | |
| SCHEMBL11965518 | 0.73 | FLT3 (0.46) | CYP19A1KDM4EKDM5CCA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11241473-B2 | Bicyclic peptide ligands and uses thereof | BICYCLETX LIMITED (GB) | 2022-02-08 | — | — | US | disclosed |
| US-20210046145-A1 | BICYCLIC PEPTIDE LIGANDS AND USES THEREOF | BICYCLETX LIMITED (GB) | 2021-02-18 | — | — | US | disclosed |
| US-10857196-B2 | Bicyclic peptide ligands and uses thereof | BICYCLETX LIMITED (GB) | 2020-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10857196-B2 | Bicyclic peptide ligands and uses thereof | VIP, NGLY1, BID | LRRK2 1345/4885CYP19A1 2220/4885KDM4E 4848/4885 |
| US-20210046145-A1 | BICYCLIC PEPTIDE LIGANDS AND USES THEREOF | VIP, NGLY1, BID | LRRK2 1345/4885CYP19A1 2220/4885KDM4E 4848/4885 |
| US-11241473-B2 | Bicyclic peptide ligands and uses thereof | VIP, NGLY1, BID | LRRK2 1345/4885CYP19A1 2220/4885KDM4E 4848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.