Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.62 |
| ▸ | ABL1 | P00519 | 15/20 | 0.62 |
| ▸ | EGFR | P00533 | 15/20 | 0.62 |
| ▸ | HCK | P08631 | 15/20 | 0.62 |
| ▸ | SRC | P12931 | 15/20 | 0.62 |
| ▸ | KDR | P35968 | 15/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.62 |
| ▸ | MTOR | P42345 | 15/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.62 |
| ▸ | PRKDC | P78527 | 15/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 14/20 | 0.62 |
| ▸ | PI4KB | Q9UBF8 | 10/20 | 0.62 |
| ▸ | BTK | Q06187 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22625427 | 0.84 | EGFR (0.66) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL23537866 | 0.84 | BTK (0.60) | EGFRBTK | |
| SCHEMBL29901532 | 0.84 | BTK (0.60) | EGFRBTK | |
| SCHEMBL16517884 | 0.84 | EGFR (0.53) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL13860271 | 0.84 | BTK (0.60) | EGFRBTK | |
| SCHEMBL17235871 | 0.83 | BTK (0.70) | BTK | |
| SCHEMBL17911430 | 0.83 | BTK (0.70) | BTK | |
| SCHEMBL29799866 | 0.83 | BTK (0.70) | BTK | |
| SCHEMBL17235723 | 0.83 | BTK (0.69) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL13860084 | 0.82 | BTK (0.59) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138842-B1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS | ZHEJIANG DTRM BIOPHARMA CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |