Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28944831 | 0.81 | ATM (0.42) | TSHRALOX15ATMPKMACHE | |
| SCHEMBL22758511 | 0.78 | CYP2C19 (0.36) | TSHRPKMPOLB | |
| SCHEMBL22749385 | 0.77 | POLB (0.44) | TSHRALOX15ATMPKMACHE | |
| SCHEMBL31382726 | 0.75 | TSHR (0.51) | TSHRALOX15ATMPKMGPR119 | |
| SCHEMBL22770324 | 0.75 | POLB (0.47) | TSHRALOX15ATMPKMPOLB | |
| SCHEMBL11963328 | 0.74 | PKM (0.44) | TSHRALOX15ATMPKMGPR119 | |
| SCHEMBL22792894 | 0.74 | POLB (0.48) | TSHRALOX15ATMPKMPOLB | |
| SCHEMBL31382411 | 0.73 | TSHR (0.49) | TSHRALOX15ATMGPR119 | |
| SCHEMBL31382020 | 0.73 | TSHR (0.51) | TSHRALOX15ATM | |
| SCHEMBL21392144 | 0.73 | CTPS1 (0.60) | TSHRALOX15ATMDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020245664-A1 | N-(5-(6-ETHOXYPYRAZIN-2-YL)PYRIDIN-2-YL)-4-(2-(METHYLSULFONAMIDO)PYRIMIDIN-4-YL) TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS HUMAN CTPS1 INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | STEP PHARMA S.A.S. (FR) | 2020-12-10 | — | — | WO | disclosed |