Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 6/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224307 | 0.91 | HTR6 (0.48) | HTR6JAK1RORCJAK2TYK2 | |
| SCHEMBL2277274 | 0.90 | HTR6 (0.48) | HTR6JAK1RORCJAK2TYK2 | |
| SCHEMBL2272526 | 0.90 | HTR6 (0.46) | HTR6JAK1RORCJAK2TYK2 | |
| SCHEMBL2278007 | 0.90 | HTR6 (0.47) | HTR6JAK1RORCJAK2TYK2 | |
| SCHEMBL2272972 | 0.88 | HTR6 (0.46) | HTR6JAK1RORCJAK2TYK2 | |
| SCHEMBL2273712 | 0.87 | HTR6 (0.45) | HTR6JAK1RORCJAK2TYK2 | |
| SCHEMBL27432817 | 0.87 | HTR6 (0.46) | HTR6RORCBCHETGFBR1CYP3A4 | |
| SCHEMBL27433422 | 0.87 | HTR6 (0.46) | HTR6RORCBCHETGFBR1GPR119 | |
| SCHEMBL2276584 | 0.87 | HTR6 (0.47) | HTR6BCHETGFBR1CYP3A4GPR119 | |
| SCHEMBL2272926 | 0.86 | HTR6 (0.45) | HTR6RORCBCHETGFBR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |