Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22748339 | 0.94 | HPGD (0.42) | HPGDLMNAMEN1KMT2AMAPK1 | |
| SCHEMBL22760338 | 0.94 | HPGD (0.42) | HPGDLMNAMEN1KMT2AMAPK1 | |
| SCHEMBL22760214 | 0.92 | MAPT (0.42) | HPGDMAPK1THRBMAPTMAPK8 | |
| SCHEMBL22760089 | 0.86 | HPGD (0.44) | HPGDLMNAMEN1KMT2AMAPK1 | |
| SCHEMBL22760057 | 0.85 | SMN1; SMN2 (0.39) | HPGDLMNAMEN1KMT2ATHRB | |
| SCHEMBL22748257 | 0.84 | MAPT (0.48) | MEN1KMT2ATHRBMAPTMAPK8 | |
| SCHEMBL22760215 | 0.84 | HPGD (0.51) | HPGDLMNAMEN1KMT2AMAPK1 | |
| SCHEMBL22748277 | 0.84 | MEN1 (0.46) | LMNAMEN1KMT2AMAPK1THRB | |
| SCHEMBL22760336 | 0.83 | MAPK8 (0.41) | LMNAKMT2AMAPTMAPK8ALDH1A1 | |
| SCHEMBL22760219 | 0.82 | MAPK8 (0.42) | HPGDLMNAMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |
| CN-112028815-A | Indole derivatives and medical application thereof | 中国药科大学 | 2020-12-04 | — | — | CN | disclosed |