⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388555 | 1.00 | — | — | |
| SCHEMBL388558 | 1.00 | — | — | |
| SCHEMBL13547450 | 0.81 | MAPT (0.43) | — | |
| SCHEMBL1725666 | 0.78 | — | — | |
| SCHEMBL18531379 | 0.78 | ALOX15 (0.46) | — | |
| SCHEMBL15341142 | 0.78 | — | — | |
| SCHEMBL6157382 | 0.78 | — | — | |
| SCHEMBL1722513 | 0.78 | — | — | |
| SCHEMBL12347467 | 0.76 | — | — | |
| SCHEMBL6210497 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250214984-A1 | COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2025-07-03 | — | — | US | disclosed |
| EP-4146645-B1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF | ONO PHARMACEUTICAL CO (JP) | 2025-06-25 | — | — | EP | disclosed |
| US-12269817-B2 | Compound having KDM5 inhibitory activity and pharmaceutical use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2025-04-08 | — | — | US | disclosed |
| EP-4471027-A1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF | ONO Pharmaceutical Co., Ltd. (JP) | 2024-12-04 | — | — | EP | disclosed |
| US-20230271952-A1 | COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-08-31 | — | — | US | disclosed |
| US-11691968-B2 | Compound having KDM5 inhibitory activity and pharmaceutical use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-07-04 | — | — | US | disclosed |
| US-20230109293-A1 | COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-04-06 | — | — | US | disclosed |
| EP-4146645-A1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF | ONO Pharmaceutical Co., Ltd. (JP) | 2023-03-15 | — | — | EP | disclosed |
| WO-2020244462-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | 中国药科大学 | 2020-12-10 | — | — | WO | disclosed |