Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22761661 | 0.81 | HSD17B10 (0.59) | HSD17B10NTRK1IDO1GAAMAPT | |
| SCHEMBL6940612 | 0.79 | MPL (0.43) | HSD17B10NTRK1IDO1GAAMAPT | |
| SCHEMBL4716917 | 0.73 | IDO1 (0.69) | HSD17B10NTRK1IDO1GAAMAPT | |
| SCHEMBL31468428 | 0.72 | TNK2 (0.41) | HSD17B10MAPT | |
| SCHEMBL22761829 | 0.70 | HSD17B10 (0.56) | HSD17B10NTRK1IDO1GAAMAPT | |
| SCHEMBL31468331 | 0.69 | MAOA (0.49) | HSD17B10LDHA | |
| SCHEMBL27490015 | 0.69 | GAA (0.45) | HSD17B10NTRK1IDO1GAAMAPT | |
| SCHEMBL1339567 | 0.68 | DYRK1A (0.56) | HSD17B10MAPT | |
| SCHEMBL1340720 | 0.68 | MAPK1 (0.42) | HSD17B10 | |
| SCHEMBL14953477 | 0.68 | KDM5B (0.39) | MAPTPRKD3PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247445-A1 | IMIDAZOLO DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS | HAGER BIOSCIENCES, LLC (US) | 2020-12-10 | — | — | WO | disclosed |