Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 3/20 | 0.53 |
| ▸ | IDO1 | P14902 | 3/20 | 0.52 |
| ▸ | TDO2 | P48775 | 3/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15173475 | 0.83 | HCRTR1 (0.46) | — | |
| SCHEMBL296168 | 0.83 | IL1B (0.41) | IL1BNPC1RAB9A | |
| SCHEMBL18734317 | 0.83 | HCRTR1 (0.46) | — | |
| SCHEMBL15173888 | 0.83 | HCRTR1 (0.46) | — | |
| SCHEMBL11896989 | 0.81 | NPC1 (0.41) | IL1BNPC1RAB9A | |
| SCHEMBL15229464 | 0.81 | IL1B (0.45) | IL1BNPC1RAB9A | |
| SCHEMBL2688541 | 0.81 | NPC1 (0.41) | IL1BNPC1RAB9A | |
| SCHEMBL6523847 | 0.81 | NPC1 (0.41) | IL1BNPC1RAB9A | |
| SCHEMBL13149783 | 0.80 | IL1B (0.46) | IL1BIDO1TDO2IRAK4CCNT1 | |
| SCHEMBL1598038 | 0.80 | IDO1 (0.49) | IL1BIDO1TDO2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247445-A1 | IMIDAZOLO DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS | HAGER BIOSCIENCES, LLC (US) | 2020-12-10 | — | — | WO | disclosed |
| WO-2020247447-A1 | PYRAZOLE AND IMIDAZOLE DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS | HAGER BIOSCIENCES, LLC (US) | 2020-12-10 | — | — | WO | disclosed |