⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17175152 | 0.66 | TSHR (0.31) | — | |
| SCHEMBL19671158 | 0.65 | — | — | |
| SCHEMBL19372785 | 0.62 | DDB1 (0.32) | — | |
| SCHEMBL18515841 | 0.57 | MAP3K14 (0.39) | — | |
| SCHEMBL20402375 | 0.55 | — | — | |
| SCHEMBL21320652 | 0.55 | — | — | |
| SCHEMBL21325326 | 0.52 | HSD17B10 (0.39) | — | |
| SCHEMBL17225912 | 0.52 | RIPK1 (0.30) | — | |
| SCHEMBL21320334 | 0.52 | — | — | |
| SCHEMBL20841455 | 0.51 | CRBN (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136346-B2 | Asymmetric auxiliary group | WAVE LIFE SCIENCES LTD. (SG) | 2021-10-05 | — | — | US | disclosed |
| US-20200385420-A1 | ASYMMETRIC AUXILIARY GROUP | WAVE LIFE SCIENCES JAPAN, INC. (JP) | 2020-12-10 | — | — | US | disclosed |