Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22763384 | 0.92 | NTRK1 (0.62) | NTRK1JAK2 | |
| SCHEMBL22763407 | 0.87 | NTRK1 (0.45) | NTRK1JAK2 | |
| SCHEMBL22762834 | 0.85 | NTRK1 (0.59) | NTRK1JAK2 | |
| SCHEMBL22763284 | 0.85 | NTRK1 (0.59) | NTRK1JAK2 | |
| SCHEMBL20597090 | 0.82 | NTRK1 (0.64) | NTRK1JAK2 | |
| SCHEMBL21588832 | 0.82 | NTRK1 (0.60) | NTRK1JAK2 | |
| SCHEMBL17830906 | 0.82 | NTRK1 (0.78) | NTRK1JAK2 | |
| SCHEMBL22763278 | 0.81 | NTRK1 (0.53) | NTRK1JAK2 | |
| SCHEMBL22763283 | 0.81 | NTRK1 (0.67) | NTRK1JAK2 | |
| SCHEMBL21588826 | 0.81 | NTRK1 (0.67) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200385386-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS AND USES THEREOF | ANGEX PHARMACEUTICAL, INC. | 2020-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200385386-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS AND USES THEREOF | MAP3K20, PNCK, CDC42BPG | NTRK1 49/4885JAK2 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.