Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276676 | 0.95 | PRKCA (0.63) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2276737 | 0.94 | PRKCA (0.49) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL394842 | 0.90 | PRKCA (0.65) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2281023 | 0.89 | PRKCA (0.55) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL392728 | 0.86 | PRKCA (0.56) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2279340 | 0.86 | PRKCA (0.42) | PRKCAMMP12CYP3A4CYP2C9OPRM1 | |
| SCHEMBL393735 | 0.85 | PRKCA (0.75) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2276740 | 0.84 | PRKCA (0.49) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL4218773 | 0.83 | PRKCA (0.44) | PRKCAMMP12CYP3A4CYP2C9OPRM1 | |
| SCHEMBL393732 | 0.83 | PRKCA (0.55) | PRKCAMMP12NR1I2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |