Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.65 |
| ▸ | MMP12 | P39900 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2272973 | 0.89 | PRKCA (0.64) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL4210853 | 0.86 | PRKCA (0.86) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL393698 | 0.84 | PRKCA (0.73) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL14110584 | 0.82 | PRKCA (0.84) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2276525 | 0.81 | PRKCA (0.53) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2274171 | 0.81 | PRKCA (0.56) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL391106 | 0.81 | PRKCA (0.63) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL393584 | 0.80 | PRKCA (0.71) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL392726 | 0.80 | PRKCA (0.64) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL2274295 | 0.79 | PRKCA (0.88) | PRKCAMMP12NR1I2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |