⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1470231 | 0.72 | — | — | |
| SCHEMBL6058725 | 0.72 | — | — | |
| SCHEMBL6058726 | 0.72 | — | — | |
| SCHEMBL2375897 | 0.67 | — | — | |
| SCHEMBL28161197 | 0.67 | — | — | |
| SCHEMBL6353382 | 0.65 | — | — | |
| SCHEMBL1515369 | 0.65 | — | — | |
| SCHEMBL647403 | 0.64 | — | — | |
| SCHEMBL7138184 | 0.62 | — | — | |
| SCHEMBL6908118 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140135311-A1 | TETRAHYDRO-PYRIMIDOAZEPINES AS MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2014-05-15 | — | — | US | claimed |
| EP-2024368-B1 | 6,7,8,9-TETRAHYDRO-5H-PYRIMIDO[4,5-D]AZEPIN-4-YL]-AMINE DERIVATIVES AS MODULATORS OF TRPV1 FOR THE TREATMENT OF PAIN | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-30 | — | — | EP | claimed |
| CN-101448835-B | 6,7,8, 9-tetrahydro-5H-pyrimido [4,5-D ] azepin-4-yl ] -amine derivatives as TRPV1 modulators for the treatment of pain | JANSSEN PHARMACEUTICA NV | 2012-06-27 | — | — | CN | claimed |
| EP-2220048-A2 | ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | Boehringer Ingelheim International GmbH (DE) | 2010-08-25 | — | — | EP | claimed |
| WO-2009063061-A2 | ARYL- AND HETEROARYLCARBONYL DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-22 | — | — | WO | claimed |
| EP-2024368-A2 | 6,7,8,9-TETRAHYDRO-5H-PYRIMIDO[4,5-D]AZEPIN-4-YL]-AMINE DERIVATIVES AS MODULATORS OF TRPV1 FOR THE TREATMENT OF PAIN | Janssen Pharmaceutica, N.V. (BE) | 2009-02-18 | — | — | EP | claimed |
| US-20070225275-A1 | Tetrahydro-pyrimidoazepines as modulators of TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-27 | — | — | US | claimed |
| WO-2007109355-A2 | 6,7,8, 9 -TETRAHYDRO- 5H- PYRIMIDO [4, 5-D] AZEPIN-4-YL] -AMINE DERIVATIVES AS MODULATORS OF TRPVL FOR THE TREATMENT OF PAIN | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-27 | — | — | WO | claimed |
| CN-110114358-B | Novel compound and pharmacologically acceptable salt thereof | 明治制果药业株式会社 | 2021-12-03 | — | — | CN | disclosed |
| US-20210315892-A1 | THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, FIBROTIC DISEASES, AND CANCER DISEASES | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2021-10-14 | — | — | US | disclosed |
| EP-3560925-B1 | NOVEL COMPOUND AND PHARMACEUTICALLY-ACCEPTABLE SALT THEREOF | MEIJI SEIKA PHARMA CO LTD (JP) | 2021-06-02 | — | — | EP | disclosed |
| EP-3815687-A1 | THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, FIBROTIC DISEASES, AND CANCER DISEASES | Meiji Seika Pharma Co., Ltd. (JP) | 2021-05-05 | — | — | EP | disclosed |
| CN-112312914-A | Therapeutic agent for inflammatory disease, autoimmune disease, fibrotic disease, and cancer disease | 明治制果药业株式会社 | 2021-02-02 | — | — | CN | disclosed |
| CN-112041746-A | Primer for semiconductor substrate and pattern forming method | 日产化学株式会社 | 2020-12-04 | — | — | CN | disclosed |
| CN-1078460-A | The method for making of hydrazone derivative and application | SUMITOMO CHEMICAL CO (JP) | 1993-11-17 | — | — | CN | disclosed |
| US-5032606-A | Novel fluorinated resorcinol ethers and their use as anti-allergics and anti-inflammatories | CIBA-GEIGY CORPORATION (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0222961-B1 | RESORCINOL ETHERS | CIBA-GEIGY AG (CH) | 1989-09-20 | — | — | EP | disclosed |
| US-4820726-A | Oxaloamino substituted fluorinated resorcinol ethers and anti-allergic and anti-inflammatory use thereof | CIBA-GEIGY CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| US-4670604-A | Novel fluorinated resorcinol ethers | CIBA-GEIGY CORPORATION (US) | 1987-06-02 | — | — | US | disclosed |
| EP-0222961-A1 | Resorcinol ethers | CIBA-GEIGY AG (CH) | 1987-05-27 | — | — | EP | disclosed |