Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | MDH2 | P40926 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247853 | 0.92 | PARP1 (0.49) | PARP1KIF11HCRTR1HCRTR2GSK3B | |
| SCHEMBL2272736 | 0.90 | PARP1 (0.43) | PARP1KIF11HCRTR1HCRTR2GSK3B | |
| SCHEMBL3793445 | 0.88 | PARP1 (0.47) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL2274667 | 0.87 | PARP1 (0.46) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL3088394 | 0.85 | PARP1 (0.48) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL393420 | 0.84 | PARP1 (0.52) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL2279243 | 0.84 | PARP1 (0.41) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL2277016 | 0.84 | PARP1 (0.43) | PARP1KIF11GSK3BCCNB2CDK1 | |
| SCHEMBL3247052 | 0.83 | PARP1 (0.42) | PARP1KIF11GSK3BALDH1A1SMN1; SMN2 | |
| SCHEMBL3939786 | 0.83 | PARP1 (0.50) | PARP1KIF11GSK3BCCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |
| EP-1764118-B1 | Polymer coating for medical devices | GILEAD PALO ALTO INC (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2010082050-A1 | MACROCYCLIC AND 7-AMINOALKYL-SUBSTITUTED BENZOXAZOCINES FOR TREATMENT OF HEPATITIS C INFECTIONS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-07-22 | — | — | WO | disclosed |
| EP-2178886-A1 | MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-04-28 | — | — | EP | disclosed |
| EP-2178885-A1 | MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-04-28 | — | — | EP | disclosed |
| EP-1937328-B1 | POLYMER COATING FOR MEDICAL DEVICES | CV THERAPEUTICS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| US-20090048239-A1 | Therapeutic compounds | MSD ITALIA S.R.L. (IT) | 2009-02-19 | — | — | US | disclosed |
| WO-2009010783-A1 | MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-01-22 | — | — | WO | disclosed |
| WO-2009010785-A1 | MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-01-22 | — | — | WO | disclosed |
| US-7419709-B2 | Polymer coating for medical devices | CV THERAPEUTICS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| WO-2007041972-A1 | POLYMER COATING FOR MEDICAL DEVICES | CV THERAPEUTICS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20070071926-A1 | Polymer coating for medical devices | RYPACEK FRANTISEK | 2007-03-29 | — | — | US | disclosed |
| US-20070071879-A1 | Polymer coating for medical devices | RYPACEK FRANTISEK | 2007-03-29 | — | — | US | disclosed |
| EP-1764118-A2 | Polymer coating for medical devices | CV THERAPEUTICS, INC. (US) | 2007-03-21 | — | — | EP | disclosed |
| US-7160592-B2 | Polymer coating for medical devices | CV THERAPEUTICS, INC. (US) | 2007-01-09 | — | — | US | disclosed |
| EP-1492581-B1 | POLYMER COATING FOR MEDICAL DEVICES | CV THERAPEUTICS INC (US) | 2006-12-20 | — | — | EP | disclosed |
| US-20060093771-A1 | Polymer coating for medical devices | CV THERAPEUTICS, INC. | 2006-05-04 | — | — | US | disclosed |
| EP-1492581-A1 | POLYMER COATING FOR MEDICAL DEVICES | CV THERAPEUTICS, INC. (US) | 2005-01-05 | — | — | EP | disclosed |
| US-20030219562-A1 | Polymer coating for medical devices | CV THERAPEUTICS, INC. | 2003-11-27 | — | — | US | disclosed |
| WO-2003068289-A1 | POLYMER COATING FOR MEDICAL DEVICES | CV THERAPEUTICS, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048239-A1 | Therapeutic compounds | RRP1B, RCE1, CTSZ | PARP1 1571/4885KIF11 3194/4885HCRTR1 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.