CTSZ — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL22639759	0.61	5/20
SCHEMBL14408085	0.56	4/20
SCHEMBL5375177	0.55	4/20
SCHEMBL4930035	0.47	4/20
SCHEMBL3346407	1.00	3/20
SCHEMBL3353019	1.00	3/20
SCHEMBL8015461	0.40	3/20
SCHEMBL3347831	1.00	2/20
SCHEMBL3350907	1.00	2/20
SCHEMBL3346441	0.75	2/20
SCHEMBL3348177	0.75	2/20
SCHEMBL3380592	0.71	2/20
SCHEMBL13363712	0.71	2/20
SCHEMBL3347915	0.70	2/20
SCHEMBL3346602	0.70	2/20
SCHEMBL4838855	0.69	2/20
SCHEMBL3346331	0.68	2/20
SCHEMBL27303713	0.61	2/20
SCHEMBL5031260	0.58	2/20
SCHEMBL14408074	0.55	2/20

Clinical trials — most relevant to CTSZ by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19	PHASE2/PHASE3	UNKNOWN
DEFINE - Evaluating Therapies for COVID-19	PHASE1/PHASE2	COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis	PHASE1/PHASE2	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis	nan	COMPLETED
Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study	nan	NOT_YET_RECRUITING
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients	nan	RECRUITING
Synovial Fluid Bank From Arthritic Patients	nan	RECRUITING
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD	nan	NOT_YET_RECRUITING
Multimodal Approach of Electrotherapy Versus Nerve Flossing Technique in Patient With Carpal Tunnel Syndrome	nan	UNKNOWN
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Hematological Markers in Idiopathic Carpal Tunnel Syndrome	nan	COMPLETED
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome	nan	RECRUITING
Fasting, Exercise, and Diet to Activate Autophagy in Depression	nan	NOT_YET_RECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Effect of Exercise on Ultrasound SWV in CTS Patients	nan	COMPLETED
Bace1as Role in Heart Failure (BACE1AS-HF)	nan	COMPLETED
Utility of Presepsin in Children Sepsis	nan	UNKNOWN
Molecular Content of Peri-implant Sulcus During Wound Healing and Osseointegration Following Drilling and Piezosurgery	nan	COMPLETED
Salivary Markers in Periodontal Disorders	nan	COMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Influence of Statins in Artery Aneurysms	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CTSZ binder may also engage these)

Protein	Name	Similarity
P05689	—	1.000	P05689 →
Q9WUU7	—	1.000	Q9WUU7 →
Q9R1T3	—	0.998	Q9R1T3 →
G5EGP8	—	0.995	G5EGP8 →
P83205	—	0.990	P83205 →
Q6PN98	—	0.989	Q6PN98 →
P25802	—	0.989	P25802 →
P07688	—	0.987	P07688 →
P90850	—	0.987	P90850 →
A1E295	—	0.987	A1E295 →
P19092	—	0.986	P19092 →
P43233	—	0.986	P43233 →
Q5R6D1	—	0.986	Q5R6D1 →
P25793	—	0.985	P25793 →
Q9SUL1	—	0.985	Q9SUL1 →
CTSB	Cathepsin B	0.984	landscape →
Q4R5M2	—	0.984	Q4R5M2 →
Q9UJW2	—	0.984	Q9UJW2 →
P00787	—	0.983	P00787 →
Q9TST1	—	0.983	Q9TST1 →
Q9R013	—	0.982	Q9R013 →
CTSC	Dipeptidyl peptidase 1	0.982	landscape →
P35591	—	0.981	P35591 →
P25775	—	0.981	P25775 →
P92132	—	0.981	P92132 →
P10605	—	0.981	P10605 →
P92133	—	0.980	P92133 →
P25250	—	0.980	P25250 →
P43509	—	0.980	P43509 →
P43296	—	0.980	P43296 →