Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 17/20 | 0.61 |
| ▸ | MET | P08581 | 14/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | MERTK | Q12866 | 11/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.59 |
| ▸ | TEK | Q02763 | 2/20 | 0.59 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.59 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22766339 | 0.90 | MET (0.74) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL21218002 | 0.87 | AXL (0.78) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL29693478 | 0.86 | AXL (0.82) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL371830 | 0.86 | AXL (0.82) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL29453534 | 0.84 | MET (0.56) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL22749893 | 0.84 | MET (0.56) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL22766341 | 0.84 | AXL (0.63) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL19373115 | 0.83 | AXL (0.72) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL21201014 | 0.83 | AXL (0.68) | AXLMETKDRMERTKNTRK1 | |
| SCHEMBL21201022 | 0.82 | AXL (0.59) | AXLMETKDRMERTKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247418-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |