Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 4/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20705833 | 0.83 | SYK (0.37) | SYKPOLBPDCD1LG2CD274CA1 | |
| SCHEMBL12569462 | 0.77 | PIM1 (0.39) | NNMTAPPPIM1PARP10 | |
| SCHEMBL5708926 | 0.77 | NNMT (0.50) | NNMTSYKSIRT6POLBCDC7 | |
| SCHEMBL2688401 | 0.77 | NNMT (0.50) | NNMTAPPSIRT6POLBCDC7 | |
| SCHEMBL24959363 | 0.76 | APP (0.43) | NNMTAPPPIM1 | |
| SCHEMBL18305261 | 0.76 | NNMT (0.49) | NNMTAPPSIRT6POLBCDC7 | |
| SCHEMBL2415642 | 0.74 | PLK1 (0.36) | SYKPOLBKDM4E | |
| SCHEMBL22688378 | 0.73 | NNMT (0.46) | NNMTAPPSIRT6POLBCDC7 | |
| SCHEMBL22842972 | 0.73 | PDCD1LG2 (0.36) | SYKPDCD1LG2CD274P2RX3P2RX2 | |
| SCHEMBL15091236 | 0.73 | PDCD1LG2 (0.40) | SYKPOLBPDCD1LG2CD274P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247160-A1 | CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-12-10 | — | — | WO | disclosed |