Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2225853 | 0.88 | ALDH1A1 (0.39) | POLBKDM4EALDH1A1TP53EGLN1 | |
| SCHEMBL2228093 | 0.86 | POLB (0.41) | POLBKDM4EALDH1A1JAK1TP53 | |
| SCHEMBL2275157 | 0.80 | ALDH1A1 (0.39) | POLBKDM4EALDH1A1TP53EGLN1 | |
| SCHEMBL2272303 | 0.78 | KDM4E (0.37) | POLBKDM4EALDH1A1TP53EGLN1 | |
| SCHEMBL2275169 | 0.74 | JAK1 (0.47) | ALDH1A1JAK1HTR6 | |
| SCHEMBL2276333 | 0.74 | JAK1 (0.52) | JAK1PKMHTR6 | |
| SCHEMBL2276890 | 0.73 | JAK1 (0.40) | POLBKDM4EALDH1A1JAK1 | |
| SCHEMBL2278926 | 0.72 | JAK1 (0.47) | JAK1HTR6 | |
| SCHEMBL2223933 | 0.71 | JAK1 (0.47) | JAK1HTR6 | |
| SCHEMBL2273246 | 0.71 | JAK1 (0.52) | JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |