Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 16/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527511 | 1.00 | GRIN2B (0.61) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL29526480 | 0.89 | GRIN2B (0.62) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL22772542 | 0.89 | GRIN2B (0.62) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL22772513 | 0.87 | GRIN2B (0.61) | GRIN2BGRIN1 | |
| SCHEMBL28677627 | 0.80 | GRIN2B (0.52) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL22772548 | 0.78 | GRIN2B (0.61) | GRIN2BGRIN1 | |
| SCHEMBL29526782 | 0.78 | GRIN2B (0.61) | GRIN2BGRIN1 | |
| SCHEMBL22772463 | 0.77 | GRIN2B (0.58) | GRIN2BGRIN1 | |
| SCHEMBL29527370 | 0.77 | GRIN2B (0.58) | GRIN2BGRIN1 | |
| SCHEMBL22772490 | 0.77 | GRIN1 (1.00) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11459336-B2 | Pyrazine carbamates and their use as GluN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-10-04 | — | — | US | disclosed |
| EP-3983072-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020249796-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020249796-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |
| US-20200392155-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | US | disclosed |
| US-20200392155-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200392155-A1 | PYRAZINE CARBAMATES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | GRIN2B, GRIN2A, GRIN2C | GRIN2B 1/4885GRIN1 4/4885KCNH2 1526/4885 |
| US-11459336-B2 | Pyrazine carbamates and their use as GluN2B receptor modulators | GRIN2B, GRIN2A, GRIN2C | GRIN2B 1/4885GRIN1 4/4885KCNH2 1526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.