Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 19/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22771375 | 0.83 | GRIN2B (0.60) | GRIN2BGRIN1 | |
| SCHEMBL22771401 | 0.83 | GRIN2B (0.61) | GRIN2BGRIN1PDGFRBPDGFRA | |
| SCHEMBL30133016 | 0.83 | GRIN2B (0.61) | GRIN2BGRIN1PDGFRBPDGFRA | |
| SCHEMBL22775758 | 0.81 | GRIN2B (0.70) | GRIN2BGRIN1 | |
| SCHEMBL22771370 | 0.79 | GRIN2B (0.61) | GRIN2BGRIN1 | |
| SCHEMBL22774149 | 0.77 | GRIN2B (0.67) | GRIN2BGRIN1 | |
| SCHEMBL22775540 | 0.75 | GRIN2B (0.73) | GRIN2BGRIN1 | |
| SCHEMBL22774766 | 0.75 | GRIN2B (0.58) | GRIN2BGRIN1 | |
| SCHEMBL22774873 | 0.75 | GRIN2B (0.57) | GRIN2BGRIN1 | |
| SCHEMBL22774798 | 0.74 | GRIN2B (0.55) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983073-A1 | SUBSTITUTED PYRAZOLO[4,3-B]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | claimed |
| WO-2020249791-A1 | SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | claimed |
| EP-3983073-A1 | SUBSTITUTED PYRAZOLO[4,3-B]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020249791-A1 | SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-17 | — | — | WO | disclosed |