Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 19/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22771401 | 1.00 | GRIN2B (0.61) | GRIN2BGRIN1PDGFRBPDGFRA | |
| SCHEMBL22774775 | 0.83 | GRIN2B (0.58) | GRIN2BGRIN1PDGFRBPDGFRA | |
| SCHEMBL22771375 | 0.81 | GRIN2B (0.60) | GRIN2BGRIN1 | |
| SCHEMBL22775758 | 0.77 | GRIN2B (0.70) | GRIN2BGRIN1 | |
| SCHEMBL22774549 | 0.76 | GRIN1 (1.00) | GRIN2BGRIN1 | |
| SCHEMBL30133039 | 0.75 | GRIN2B (0.58) | GRIN2BGRIN1 | |
| SCHEMBL22771370 | 0.75 | GRIN2B (0.61) | GRIN2BGRIN1 | |
| SCHEMBL29901549 | 0.75 | GRIN1 (0.78) | GRIN2BGRIN1 | |
| SCHEMBL22771406 | 0.74 | GRIN2B (0.58) | GRIN2BGRIN1 | |
| SCHEMBL30133049 | 0.74 | GRIN2B (0.58) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324860-A1 | SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324860-A1 | SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | GRIN2B, GRIN3B, GRIN3A | GRIN2B 1/4885GRIN1 7/4885PDGFRB 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.