SCHEMBL22776396

SCHEMBL22776396

Nc1c2cc3ccccc3cc2cc2cc3ccccc3cc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.50
HSD17B10 Q99714 6/20 0.50
CYP3A4 P08684 3/20 0.50
CASP1 P29466 3/20 0.50
CASP7 P55210 3/20 0.50
HIF1A Q16665 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
ALOX15 P16050 1/20 0.50
HBB P68871 1/20 0.50
KDM4E B2RXH2 5/20 0.44
HPGD P15428 5/20 0.44
GLA P06280 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
ACHE P22303 2/20 0.44
CHRM2 P08172 1/20 0.44
ADRA2A P08913 1/20 0.44
ADORA3 P0DMS8 1/20 0.44
CHRM1 P11229 1/20 0.44
NQO2 P16083 1/20 0.44
MAOA P21397 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27763980 0.93 ALDH1A1 (0.44) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL10326065 0.93 ALDH1A1 (0.48) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL30134418 0.91 ALDH1A1 (0.46) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL3317872 0.85 ALDH1A1 (0.43) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL28505194 0.85 ALDH1A1 (0.50) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL28390833 0.85 ALDH1A1 (0.50) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL28318733 0.83 ALDH1A1 (0.50) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL168352 0.80 ALDH1A1 (0.48) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL29407363 0.80 ALDH1A1 (0.48) ALDH1A1HSD17B10CYP3A4CASP1CASP7
SCHEMBL4928668 0.80 ALDH1A1 (0.39) ALDH1A1HSD17B10CYP3A4CASP1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020250700-A1 POLYCYCLIC AROMATIC COMPOUND 学校法人関西学院 2020-12-17 WO disclosed