Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 13/20 | 0.43 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL22777264 | 1.00 | ATF4 (0.48) | ATF4HTR7SCN9ASCN7AKCNH2 | |
| SCHEMBL23920238 | 0.93 | ATF4 (0.51) | ATF4HTR7SCN9ASCN7AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL21050177 | 0.89 | SMYD3 (0.50) | ATF4HTR7SCN9ASCN7AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL21050179 | 0.89 | SMYD3 (0.50) | ATF4HTR7SCN9ASCN7AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL22777442 | 0.85 | ATF4 (0.37) | ATF4 | |
| Trifluoroacetic Acid SCHEMBL22777440 | 0.85 | ATF4 (0.37) | ATF4 | |
| Trifluoroacetic Acid SCHEMBL21050218 | 0.85 | SCN9A (0.56) | ATF4HTR7SCN9ASCN7AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL22777258 | 0.84 | ATF4 (0.55) | ATF4HTR7SCN9ACNR1 | |
| Trifluoroacetic Acid SCHEMBL29447019 | 0.84 | ATF4 (0.55) | ATF4HTR7SCN9ACNR1 | |
| SCHEMBL21050164 | 0.81 | ATF4 (0.52) | ATF4HTR7SCN9ASCN7AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983378-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2022-04-20 | — | — | EP | disclosed |
| CN-114206829-A | Integrated stress response pathway inhibitors | 普拉西斯生物技术有限责任公司 | 2022-03-18 | — | — | CN | disclosed |
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2021-10-14 | — | — | US | disclosed |
| WO-2020252205-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885HTR7 922/4885SCN9A 4611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.