SCHEMBL22777464

SCHEMBL22777464

CCCN(CCCNC(=O)O)C(=O)C1=Cc2ccc(Br)cc2N=C(N)C1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 20/20 0.59
TLR7 Q9NYK1 7/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1239780 0.89 TLR8 (0.69) TLR8TLR7
SCHEMBL22770869 0.88 TLR8 (0.54) TLR8TLR7
SCHEMBL28771849 0.86 TLR8 (0.63) TLR8TLR7
SCHEMBL22771001 0.86 TLR8 (0.60) TLR8TLR7
SCHEMBL27078327 0.86 TLR8 (0.83) TLR8TLR7
SCHEMBL23165953 0.84 TLR8 (0.71) TLR8TLR7
SCHEMBL29280545 0.84 TLR8 (0.85) TLR8TLR7
SCHEMBL22770868 0.84 TLR8 (0.58) TLR8TLR7
SCHEMBL29280560 0.84 TLR8 (0.82) TLR8TLR7
SCHEMBL28771670 0.83 TLR8 (0.59) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3983082-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF Bolt Biotherapeutics, Inc. (US) 2022-04-20 EP disclosed
EP-3983080-A1 MACROMOLECULE-SUPPORTED AMINOBENZAZEPINE COMPOUNDS Bolt Biotherapeutics, Inc. (US) 2022-04-20 EP disclosed
WO-2021067242-A1 AMIDE-LINKED, AMINOBENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2021-04-08 WO disclosed
WO-2020252254-A1 MACROMOLECULE-SUPPORTED AMINOBENZAZEPINE COMPOUNDS BOLT BIOTHERAPEUTICS, INC. (US) 2020-12-17 WO disclosed
WO-2020252294-A1 AMINOBENZAZEPINE COMPOUNDS, IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2020-12-17 WO disclosed