Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 10/20 | 0.46 |
| ▸ | GRM5 | P41594 | 9/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22777065 | 0.86 | HTR6 (0.60) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL22776412 | 0.82 | SMARCA2 (0.47) | HTR6SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL20111981 | 0.79 | HTR6 (0.61) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL20111995 | 0.79 | HTR6 (0.57) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL29910459 | 0.77 | SMARCA2 (0.66) | HTR6PDK4GRM1GRM5SMARCA2 | |
| SCHEMBL20009091 | 0.77 | SMARCA2 (0.66) | HTR6PDK4GRM1GRM5SMARCA2 | |
| SCHEMBL22777343 | 0.76 | PDK4 (0.52) | HTR6PDK4GRM1GRM5SMARCA2 | |
| SCHEMBL18080760 | 0.76 | HTR6 (0.64) | HTR6PDK4GRM1GRM5SCN9A | |
| SCHEMBL12712612 | 0.76 | PDK4 (0.69) | HTR6PDK4GRM1GRM5SMARCA2 | |
| SCHEMBL31548741 | 0.73 | SMARCA2 (0.62) | PDK4GRM1GRM5SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324880-A1 | SMARCA INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-10-13 | — | — | US | disclosed |
| WO-2020251974-A1 | SMARCA INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220324880-A1 | SMARCA INHIBITORS AND USES THEREOF | SMARCA1, SMARCE1, PBRM1 | HTR6 3591/4885PDK4 3698/4885GRM1 3498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.