Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18248309 | 0.86 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL18248420 | 0.86 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL30018199 | 0.86 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL30018512 | 0.86 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL18255052 | 0.86 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL18248275 | 0.85 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL18248359 | 0.85 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL18248332 | 0.83 | RIPK1 (1.00) | RIPK1ALDH1A1 | |
| SCHEMBL18248385 | 0.83 | RIPK1 (0.69) | RIPK1 | |
| SCHEMBL30017968 | 0.83 | RIPK1 (0.69) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298002-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-12-16 | — | — | EP | disclosed |