Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.43 |
| ▸ | FLT1 | P17948 | 9/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12411884 | 0.84 | KDR (0.45) | KDRFLT1METPDGFRAKIT | |
| SCHEMBL12376874 | 0.80 | AXL (0.55) | KDRFLT1METKIT | |
| SCHEMBL2283266 | 0.79 | KDR (0.36) | KDRFLT1MET | |
| SCHEMBL2287299 | 0.79 | MET (0.61) | KDRMETPDGFRAKIT | |
| SCHEMBL2283258 | 0.77 | MET (0.49) | KDRMET | |
| SCHEMBL2284520 | 0.76 | MET (0.49) | KDRMET | |
| SCHEMBL2284724 | 0.76 | MET (0.49) | KDRMET | |
| SCHEMBL12376879 | 0.74 | AXL (0.48) | KDRFLT1METKIT | |
| SCHEMBL2285742 | 0.74 | MET (0.48) | KDRMET | |
| SCHEMBL2282899 | 0.74 | KDR (0.38) | KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | KDR 419/4885FLT1 371/4885MET 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.