Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273339 | 0.88 | JAK3 (0.43) | SYKKCNH2CYP2D6MAP4K1CYP2C9 | |
| SCHEMBL3063499 | 0.87 | MAP4K1 (0.40) | SYKKCNH2CYP2D6MAP4K1NTRK1 | |
| SCHEMBL2274317 | 0.86 | SYK (0.39) | SYKKCNH2CYP2D6MAP4K1CYP2C9 | |
| SCHEMBL2278401 | 0.84 | SYK (0.41) | SYKKCNH2CYP2D6MAP4K1CYP2C9 | |
| SCHEMBL2345331 | 0.78 | MAP4K1 (0.38) | SYKKCNH2CYP2D6MAP4K1NTRK1 | |
| SCHEMBL1368438 | 0.78 | JAK3 (0.48) | JAK3 | |
| SCHEMBL2277129 | 0.77 | SYK (0.44) | SYKKCNH2CYP2D6CYP2C9JAK3 | |
| SCHEMBL2343883 | 0.76 | JAK3 (0.39) | SYKKCNH2MAP4K1CYP2C9JAK3 | |
| SCHEMBL2275753 | 0.76 | SYK (0.41) | SYKKCNH2CYP2D6CYP2C9JAK3 | |
| SCHEMBL2275620 | 0.76 | JAK3 (0.43) | SYKKCNH2CYP2D6MAP4K1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | claimed |
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | disclosed |